Notes : One of the two major Starbase designs fielded in the 2340's the Starbase 375 variant is the more combat oriented of the two. Compared to the Starbase 173 design the station has reduced scientific facilities, without the telescope dome, and a reduced capability to handle civilian traffic. The base is also designed to operate largely within planetary systems, and as such lacks Starbase 173's large bulk cargo and fuel containers. More space is given over to weaponry, with roughly double the armament. The shield generator is identical between the two stations, but the removal of the cargo containers means that Starbase 375's shields need to cover a significantly smaller volume, and this increases their overall strength.

Starbase 375 was established near to the Cardassian border, and was an important base during the Dominion war. Admiral Ross was based on the station, along with his aide Captain Sisko. Many important operations were planned and staged from here, including the operation to destroy the Dominions advanced sensor system and the operation to retake Deep Space Nine.